103412-37-9
Chemical Structure
B4148
- CAS No.: 103412-37-9
- Formula:C62H95N19O14S2
- Molecular Weight:1394.67
IUPAC Name: ((S)-2-((R)-2-((S)-2-((S)-2-(2-((S)-1-((2S,4R)-1-(L-lysyl-L-lysyl-L-arginyl)-4-hydroxypyrrolidine-2-carbonyl)pyrrolidine-2-carboxamido)acetamido)-3-(thiophen-2-yl)propanamido)-3-hydroxypropanamido)-3-phenylpropanamido)-3-(thiophen-2-yl)propanoyl)-L-argini
InChIKey: UXKJOENWINNTON-BYZYXFGASA-N
SMILES: O=C(N1[C@@H](CCC1)C(NCC(N[C@H](C(N[C@@H](CO)C(N[C@@H](C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CC2=CC=CS2)=O)CC3=CC=CC=C3)=O)=O)CC4=CC=CS4)=O)=O)[C@H]5N(C[C@@H](C5)O)C([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@@H](N)CCCCN)=O)=O)=O
Biological Activity: B4148 is a selective competitive bradykinin (BK) antagonist that significantly inhibits BK-induced hypotension in rats. In a rat model of endotoxin shock induced by Escherichia coli lipopolysaccharide, B4148 significantly attenuated the decrease in mean arterial blood pressure compared with the control group[1].
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B4148 | B4148 is a selective competitive bradykinin (BK) antagonist that significantly inhibits BK-induced hypotension in rats. In a rat model of endotoxin shock induced by Escherichia coli lipopolysaccharide, B4148 significantly attenuated the decrease in mean arterial blood pressure compared with the control group. | |||||||||||||||||||||
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Keywords
