1037826-77-9
Chemical Structure
A-953227
- CAS No.: 1037826-77-9
- Formula:C25H20FN5O3
- Molecular Weight:457.46
IUPAC Name: N-(4-amino-3,4-dioxo-1-phenylbutan-2-yl)-2-(3-(4-fluorophenyl)-1H-pyrazol-1-yl)nicotinamide
InChIKey: CJFKGISBMQMNDQ-UHFFFAOYSA-N
SMILES: O=C(C1=C(N=CC=C1)N2N=C(C=C2)C3=CC=C(C=C3)F)NC(CC4=CC=CC=C4)C(C(N)=O)=O
Biological Activity: A-953227 is a highly potent and selective inhibitor with the activity of inhibiting calcium-dependent esterase (calpain). A-953227 has enhanced selectivity for related cysteine proteases (cathepsins) and has shown good efficacy in cell experiments. A-953227 has shown broad efficacy in preclinical models for Alzheimer's disease, suggesting that it has potential benefits in inhibiting Alzheimer's disease[1].
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A-953227 | A-953227 is a highly potent and selective inhibitor with the activity of inhibiting calcium-dependent esterase (calpain). A-953227 has enhanced selectivity for related cysteine proteases (cathepsins) and has shown good efficacy in cell experiments. A-953227 has shown broad efficacy in preclinical models for Alzheimer's disease, suggesting that it has potential benefits in inhibiting Alzheimer's disease. | |||||||||||||||||||||
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Keywords
