1048973-47-2
1048973-47-2
Chemical Structure
MDA 19
Synonym(s): BZO-HEXOXIZID
- CAS No.: 1048973-47-2
- Formula:C21H23N3O2
- Molecular Weight:349.43
IUPAC Name: (Z)-N'-(1-hexyl-2-oxoindolin-3-ylidene)benzohydrazide
InChIKey: ZGQHMZCITJHYOW-QOCHGBHMSA-N
SMILES: O=C(N/N=C1C(N(CCCCCC)C2=C\1C=CC=C2)=O)C3=CC=CC=C3
Biological Activity: MDA 19 is a potent and selective agonist of human cannabinoid receptor 2 (CB2), with a Ki of 43.3 nM. MDA 19 has antiallodynic effects in a rat model of neuropathic pain and does not affect rat locomotor activity[1][2].
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MDA 19 | 98.80% | MDA 19 is a potent and selective agonist of human cannabinoid receptor 2 (CB2), with a Ki of 43.3 nM. MDA 19 has antiallodynic effects in a rat model of neuropathic pain and does not affect rat locomotor activity. | ||||||||||||||||||||
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MDA 19 (Standard) | ≥98% | MDA 19 (Standard) is the analytical standard of MDA 19. This product is intended for research and analytical applications. MDA 19 is a potent and selective agonist of human cannabinoid receptor 2 (CB2), with a Ki of 43.3 nM. MDA 19 has antiallodynic effects in a rat model of neuropathic pain and does not affect rat locomotor activity. | ||||||||||||||||||||
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References
- [1]. Diaz, Philippe; Xu, Jijun; Astruc-Diaz, Fanny et al. Design and Synthesis of a Novel Series of N-Alkyl Isatin Acylhydrazone Derivatives that Act as Selective Cannabinoid Receptor 2 Agonists for the Treatment of Neuropathic Pain. Journal of Medicinal Chemistry (2008), 51(16), 4932-4947. [Content Brief]
- [2]. Xu JJ, Diaz P, Astruc-Diaz F et al. Pharmacological characterization of a novel cannabinoid ligand, MDA19, for treatment of neuropathic pain. Anesth Analg. 2010 Jul;111(1):99-109. [Content Brief]
Keywords
