1056016-06-8
1056016-06-8
Chemical Structure
(R)-DRF053
- CAS No.: 1056016-06-8
- Formula:C23H27N7O
- Molecular Weight:417.51
IUPAC Name: (R)-2-((9-isopropyl-6-((3-(pyridin-2-yl)phenyl)amino)-9H-purin-2-yl)amino)butan-1-ol
InChIKey: LWANFAFTTOKZAX-QGZVFWFLSA-N
SMILES: CC(C)N1C2=NC(N[C@@H](CO)CC)=NC(NC3=CC(C4=CC=CC=N4)=CC=C3)=C2N=C1
Biological Activity: (R)-DRF053 is a CDK inhibitor. (R)-DRF053 inhibits Cdk5 and promotes the formation of ductal precursor β cells. (R)-DRF053 inhibits Dil-ox-LDL uptake and CD36 gene expression induced by advanced glycation end products (AGEs) in U937 cells[1][2].
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(R)-DRF053 | (R)-DRF053 is a CDK inhibitor. (R)-DRF053 inhibits Cdk5 and promotes the formation of ductal precursor β cells. (R)-DRF053 inhibits Dil-ox-LDL uptake and CD36 gene expression induced by advanced glycation end products (AGEs) in U937 cells. | |||||||||||||||||||||
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References
- [1]. Liu KC, et al. Inhibition of Cdk5 Promotes β-Cell Differentiation From Ductal Progenitors. Diabetes. 2018 Jan;67(1):58-70. [Content Brief]
- [2]. Yashima H, et al. AGE-RAGE Axis Stimulates Oxidized LDL Uptake into Macrophages through Cyclin-Dependent Kinase 5-CD36 Pathway via Oxidative Stress Generation. Int J Mol Sci. 2020 Dec 4;21(23):9263. [Content Brief]
Keywords
