1060968-92-4
1060968-92-4
Chemical Structure
E17241
- CAS No.: 1060968-92-4
- Formula:C15H14N2O2S2
- Molecular Weight:318.41
IUPAC Name: 4-(1,3-dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide
InChIKey: IOZLWSWLSUBSJM-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C2SCCS2)C=C1)NC3=NC=CC=C3O
Biological Activity: E17241 is an inducer of the expression of ABCA1 that increases the protein levels of ABCA1 in RAW 264.7 macrophages. E17241 is also an agonist of peroxisome proliferator-activated receptors (PPARs ). E17241 decreases plasma glucose levels and body weight in KKAy diabetic mice fed a high-fat and high-glucose (HFHG) diet[1][2].
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E17241 | 95.04% | E17241 is an inducer of the expression of ABCA1 that increases the protein levels of ABCA1 in RAW 264.7 macrophages. E17241 is also an agonist of peroxisome proliferator-activated receptors (PPARs ). E17241 decreases plasma glucose levels and body weight in KKAy diabetic mice fed a high-fat and high-glucose (HFHG) diet. | ||||||||||||||||||||
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References
- [1]. Sheng R, et al. A pan-PPAR agonist E17241 ameliorates hyperglycemia and diabetic dyslipidemia in KKAy mice via up-regulating ABCA1 in islet, liver, and white adipose tissue. Biomed Pharmacother. 2024 Mar;172:116220. [Content Brief]
- [2]. Xu Y, et al. E17241 as a novel ABCA1 (ATP-binding cassette transporter A1) upregulator ameliorates atherosclerosis in mice[J]. Arteriosclerosis, Thrombosis, and Vascular Biology, 2021, 41(6): e284-e298. [Content Brief]
Keywords
