1061605-35-3
1061605-35-3
Chemical Structure
CC-647
- CAS No.: 1061605-35-3
- Formula:C23H22N2O5
- Molecular Weight:406.43
InChIKey: KTDDHJCPFRGLJQ-UHFFFAOYSA-N
SMILES: O=C1C2=C(C(N1C3C(NC(CC3)=O)=O)=O)C(OC4=CC=CC(C(C)(C)C)=C4)=CC=C2
Biological Activity: CC-647 is a molecular glue modulator targeting Cereblon (CRBN) E3 ubiquitin ligase. CC-647 promotes the interaction between CRBN and ZBTB16 as well as its oncogenic fusion protein RARα-ZBTB16 (with a DC50 of 103 nM). CC-647 is promising for research of ZBTB16-RARα-associated acute promyelocytic leukemia (APL)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CC-647 | 99.58% | CC-647 is a molecular glue modulator targeting Cereblon (CRBN) E3 ubiquitin ligase. CC-647 promotes the interaction between CRBN and ZBTB16 as well as its oncogenic fusion protein RARα-ZBTB16 (with a DC50 of 103 nM). CC-647 is promising for research of ZBTB16-RARα-associated acute promyelocytic leukemia (APL). | ||||||||||||||||||||
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References
Keywords
