1092977-06-4
1092977-06-4
Chemical Structure
Evenamide hydrochloride
Synonym(s): NW-3509 hydrochloride
- CAS No.: 1092977-06-4
- Formula:C16H27ClN2O2
- Molecular Weight:314.85
IUPAC Name: 2-((3-butoxyphenethyl)amino)-N,N-dimethylacetamide hydrochloride
InChIKey: DXNSJWVLSBMXNR-UHFFFAOYSA-N
SMILES: O=C(CNCCC1=CC=CC(OCCCC)=C1)N(C)C.Cl
Biological Activity: Evenamide hydrochloride is an orally available voltage-gated sodium channel (VGSC) blocker (Ki=0.4 μM) for the research of schizophrenia. Evenamide hydrochloride shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness[1][2].
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Evenamide hydrochloride | Evenamide hydrochloride is an orally available voltage-gated sodium channel (VGSC) blocker (Ki=0.4 μM) for the research of schizophrenia. Evenamide hydrochloride shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness. | |||||||||||||||||||||
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References
- [1]. Valentina Zuliani, et al. Advances in Design and Development of Sodium Channel Blockers. Ion Channels and Their Inhibitors pp 79-115.
- [2]. Faravelli, et al. P.3.f.022 Evenamide (formerly NW-3509) targets new mechanisms, and represents a new approach to the management of untreated symptoms in schizophrenia.
Keywords
