110124-55-5
110124-55-5
Chemical Structure
MDL 27032
- CAS No.: 110124-55-5
- Formula:C11H12N2O2
- Molecular Weight:204.23
IUPAC Name: 4-propyl-5-(pyridin-4-yl)oxazol-2(3H)-one
InChIKey: BOCATKBAKISRLA-UHFFFAOYSA-N
SMILES: CCCC(N1)=C(C2=CC=NC=C2)OC1=O
Biological Activity: MDL 27032 is an active site-directed inhibitor of protein kinase C (PKC) and cAMP-dependent protein kinase (PKA) with Ki values of 24 and 14.3μM. MDL 27032 can relaxe vascular smooth muscle and can be used as vasodilator[1].
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MDL 27032 | MDL 27032 is an active site-directed inhibitor of protein kinase C (PKC) and cAMP-dependent protein kinase (PKA) with Ki values of 24 and 14.3μM. MDL 27032 can relaxe vascular smooth muscle and can be used as vasodilator. | |||||||||||||||||||||
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References
- [1]. Robinson P J, et al. MDL 27,032 [4-propyl-5-(4-pyridinyl)-2 (3H)-oxazolone], an active site-directed inhibitor of protein kinase C and cyclic AMP-dependent protein kinase that relaxes vascular smooth muscle[J]. The Journal of pharmacology and experimental therapeutics, 1990, 255(3): 1392-1398. [Content Brief]
Keywords
