112018-00-5
112018-00-5
Chemical Structure
Tebufelone
Synonym(s): NE-11740
- CAS No.: 112018-00-5
- Formula:C20H28O2
- Molecular Weight:300.44
IUPAC Name: 1-(3,5-di-tert-butyl-4-hydroxyphenyl)hex-5-yn-1-one
InChIKey: ZHXUEUKVDMWSKV-UHFFFAOYSA-N
SMILES: OC1=C(C=C(C(CCCC#C)=O)C=C1C(C)(C)C)C(C)(C)C
Biological Activity: Tebufelone (NE-11740), a nonsteroidal anti-inflammatory drug (NSAID), is a selective dual COX-2/5-lipoxygenase inhibitor. Tebufelone displays potent anti-inflammatory, analgesic and anti-pyretic properties[1][2].
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Tebufelone | 99.52% | Tebufelone (NE-11740), a nonsteroidal anti-inflammatory drug (NSAID), is a selective dual COX-2/5-lipoxygenase inhibitor. Tebufelone displays potent anti-inflammatory, analgesic and anti-pyretic properties. | ||||||||||||||||||||
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References
- [1]. S M Weisman, et al. Effects of tebufelone (NE-11740), a new anti-inflammatory drug, on arachidonic acid metabolism. Agents Actions. 1994 May;41(3-4):156-63. [Content Brief]
- [2]. Sebastian Braun, et al. Carborane-Based Tebufelone Analogs and Their Biological Evaluation In Vitro. ChemMedChem. 2023 Jul 17;18(14):e202300206. [Content Brief]
