1122-47-0
1122-47-0
Chemical Structure
1-Methylcytosine
- CAS No.: 1122-47-0
- Formula:C5H7N3O
- Molecular Weight:125.13
IUPAC Name: 4-amino-1-methylpyrimidin-2(1H)-one
InChIKey: HWPZZUQOWRWFDB-UHFFFAOYSA-N
SMILES: NC(C=CN1C)=NC1=O
Biological Activity: 1-Methylcytosine is a pyrimidinone that serves as a nucleobase for hachimoji DNA and pairs with isoguanine. 1-Methylcytosine exerts weak antiproliferative activity against cervical cancer cells. 1-Methylcytosine can be used in the research of cervical cancer[1][2].
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1-Methylcytosine | 99.01% | 1-Methylcytosine is a pyrimidinone that serves as a nucleobase for hachimoji DNA and pairs with isoguanine. 1-Methylcytosine exerts weak antiproliferative activity against cervical cancer cells. 1-Methylcytosine can be used in the research of cervical cancer. | ||||||||||||||||||||
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1-Methylcytosine (Standard) | ≥98% | 1-Methylcytosine is a methylated form of the DNA base cytosine and used as a nucleobase of hachimoji DNA, in which it pairs with Isoguanine. | ||||||||||||||||||||
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References
- [1]. Noll S, et al. Synthesis of modified pyrimidine bases and positive impact of chemically reactive substituents on their in vitro antiproliferative activity. Eur J Med Chem. 2009;44(3):1172-1179. [Content Brief]
- [2]. Ruiz J, et al. New palladium(II) and platinum(II) complexes with the model nucleobase 1-methylcytosine: antitumor activity and interactions with DNA. Inorg Chem. 2005;44(21):7365-7376. [Content Brief]
