112727-80-7
112727-80-7
Chemical Structure
Renzapride
Synonym(s): BRL 24924
- CAS No.: 112727-80-7
- Formula:C16H22ClN3O2
- Molecular Weight:323.82
IUPAC Name: 4-amino-N-((4S,5R)-1-azabicyclo[3.3.1]nonan-4-yl)-5-chloro-2-methoxybenzamide
InChIKey: GZSKEXSLDPEFPT-YGRLFVJLSA-N
SMILES: ClC1=C(N)C=C(OC)C(C(N[C@H]2CCN3CCC[C@@H]2C3)=O)=C1
Biological Activity: Renzapride (BRL 24924), a substituted benzamide, is a full 5-HT4 receptor agonist with a Ki value of 115 nM. Renzapride (BRL 24924) is also a 5HT2b and 5HT3 receptor antagonist[1]. Renzapride could be used for constipation predominant irritable bowel syndrome (C-IBS) study[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Renzapride | 99.20% | Renzapride (BRL 24924), a substituted benzamide, is a full 5-HT4 receptor agonist with a Ki value of 115 nM. Renzapride (BRL 24924) is also a 5HT2b and 5HT3 receptor antagonist. Renzapride could be used for constipation predominant irritable bowel syndrome (C-IBS) study. | ||||||||||||||||||||
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References
- [1]. Camilleri M, et al. Effect of renzapride on transit in constipation-predominant irritable bowel syndrome. Clin Gastroenterol Hepatol. 2004;2(10):895-904. [Content Brief]
- [2]. Scarpellini E, et al. Renzapride: a new drug for the treatment of constipation in the irritable bowel syndrome. Expert Opin Investig Drugs. 2008;17(11):1663-1670. [Content Brief]
