1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. Renzapride

Renzapride (Synonyms: BRL 24924)

Cat. No.: HY-14147
Handling Instructions

Renzapride (BRL 24924), a substituted benzamide, is a full 5-HT4 receptor agonist with a Ki value of 115 nM. Renzapride (BRL 24924) is also a 5HT2b and 5HT3 receptor antagonist. Renzapride could be used for constipation predominant irritable bowel syndrome (C-IBS) study.

For research use only. We do not sell to patients.

Renzapride Chemical Structure

Renzapride Chemical Structure

CAS No. : 112727-80-7

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Description

Renzapride (BRL 24924), a substituted benzamide, is a full 5-HT4 receptor agonist with a Ki value of 115 nM. Renzapride (BRL 24924) is also a 5HT2b and 5HT3 receptor antagonist[1]. Renzapride could be used for constipation predominant irritable bowel syndrome (C-IBS) study[2].

IC50 & Target[1]

5-HT4 Receptor

115 nM (Ki)

In Vitro

Renzapride replaces specific binding of [H3] GR 113808 (a selective 5-HT receptor antagonist) to cloned human 5-HT4 receptors with a Ki value of 115 nM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Renzapride (BRL 24924) (100 µg i.v.) results in a partial reverse of both the delayed solid and liquid meals emptying[2].
Renzapride (BRL 24924) (0.5-1 mg/kg) significantly increases the rate of emptying of a 51Cr-labeled liquid meal from the murine stomach[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Dog (simulating gastroparesis)[2]
Dosage: 100 µg/kg
Administration: i.v.
Result: Results in a partial reverse of both the delayed solid and liquid meals emptying.
Animal Model: Mice (30-45g)[2]
Dosage: 0.5-1 mg/kg
Administration: p.o.
Result: Significantly increase the rate of emptying of a 51Cr-labeled liquid meal from the murine stomach.
Molecular Weight

323.82

Formula

C₁₆H₂₂ClN₃O₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Renzapride
Cat. No.:
HY-14147
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