2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. (S)-Renzapride

(S)-Renzapride  (Synonyms: (S)-BRL 24924)

Cat. No.: HY-14147A Purity: 98.06%
COA Handling Instructions

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(S)-Renzapride ((S)-BRL 24924) is the isomer of HY-14147 Renzapride. Renzapride is a 5-HT4 receptor agonist with a Ki value of 115 nM. Renzapride also is a 5HT2b and 5HT3 receptor antagonist. Renzapride can be used for constipation predominant irritable bowel syndrome (C-IBS) study.

For research use only. We do not sell to patients.

(S)-Renzapride Chemical Structure

(S)-Renzapride Chemical Structure

Size Price Stock Quantity
5 mg USD 450 In-stock
10 mg USD 800 In-stock
25 mg USD 1650 In-stock
50 mg USD 2550 In-stock
100 mg USD 3800 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

(S)-Renzapride Related Antibodies

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

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Description

(S)-Renzapride ((S)-BRL 24924) is the isomer of HY-14147 Renzapride. Renzapride is a 5-HT4 receptor agonist with a Ki value of 115 nM. Renzapride also is a 5HT2b and 5HT3 receptor antagonist. Renzapride can be used for constipation predominant irritable bowel syndrome (C-IBS) study[1][2].

Molecular Weight

323.82

Formula

C16H22ClN3O2
Appearance

Solid

Color

White to off-white

SMILES

ClC1=C(N)C=C(OC)C(C(N[C@H]2CCN3CCC[C@H]2C3)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 35 mg/mL (108.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0881 mL 15.4407 mL 30.8814 mL
5 mM 0.6176 mL 3.0881 mL 6.1763 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0881 mL 15.4407 mL 30.8814 mL 77.2034 mL
5 mM 0.6176 mL 3.0881 mL 6.1763 mL 15.4407 mL
10 mM 0.3088 mL 1.5441 mL 3.0881 mL 7.7203 mL
15 mM 0.2059 mL 1.0294 mL 2.0588 mL 5.1469 mL
20 mM 0.1544 mL 0.7720 mL 1.5441 mL 3.8602 mL
25 mM 0.1235 mL 0.6176 mL 1.2353 mL 3.0881 mL
30 mM 0.1029 mL 0.5147 mL 1.0294 mL 2.5734 mL
40 mM 0.0772 mL 0.3860 mL 0.7720 mL 1.9301 mL
50 mM 0.0618 mL 0.3088 mL 0.6176 mL 1.5441 mL
60 mM 0.0515 mL 0.2573 mL 0.5147 mL 1.2867 mL
80 mM 0.0386 mL 0.1930 mL 0.3860 mL 0.9650 mL
100 mM 0.0309 mL 0.1544 mL 0.3088 mL 0.7720 mL
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(S)-Renzapride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-Renzapride(S)-BRL 249245-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorisomerRenzapridebenzamidC-IBSIBSirritablebowelsyndromeInhibitorinhibitorinhibit

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