112891-97-1
Chemical Structure
Alentemol
Synonym(s): U-66444B free base
- CAS No.: 112891-97-1
- Formula:C19H25NO
- Molecular Weight:283.41
IUPAC Name: 2-(dipropylamino)-2,3-dihydro-1H-phenalen-5-ol
InChIKey: TWUJBHBRYYTEDL-UHFFFAOYSA-N
SMILES: OC1=CC2=C3C(CC(N(CCC)CCC)C2)=CC=CC3=C1
Biological Activity: Alentemol (U-66444B (free base)) is a blood-brain barrier-permeable dopamine receptor D1, D2, D3, and D4 agonist. Alentemol inhibits dopamine release, reduces dopamine synthesis, regulates dopamine metabolism, suppresses the impulse activity of dopaminergic neurons, and decreases the impulse frequency of dopaminergic neurons in the substantia nigra pars compacta and ventral tegmental area. Alentemol is applicable to research related to schizophrenia[1][2][3].
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Alentemol | Alentemol (U-66444B (free base)) is a blood-brain barrier-permeable dopamine receptor D1, D2, D3, and D4 agonist. Alentemol inhibits dopamine release, reduces dopamine synthesis, regulates dopamine metabolism, suppresses the impulse activity of dopaminergic neurons, and decreases the impulse frequency of dopaminergic neurons in the substantia nigra pars compacta and ventral tegmental area. Alentemol is applicable to research related to schizophrenia. | |||||||||||||||||||||
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References
- [1]. Von Voigtlander PF, et al. Dopamine receptor agonist activity of U‑66444B and its enantiomers: Evaluation of functional, biochemical, and pharmacokinetic properties. Drug Development Research. 1989;17(1):71‑81.
- [2]. Piercey MF, et al. Neurotransmitter Release and Impulse Frequency Studies of Dopaminergic Autoreceptor Agonists. Annals of the New York Academy of Sciences. 1990;604(1):637‑638.
- [3]. Ceci A., et al. Pharmaceutical composition comprising 2 , 3-disubstituted tropanes for the treatment of disorders of sexual desire. Germany, WO2007006738 A. 2007-01-18.
