112891-97-1
Chemical Structure
Alentemol
Synonym(s): U-66444B free base
- CAS No.: 112891-97-1
- Formula:C19H25NO
- Molecular Weight:283.41
IUPAC Name: 2-(dipropylamino)-2,3-dihydro-1H-phenalen-5-ol
InChIKey: TWUJBHBRYYTEDL-UHFFFAOYSA-N
SMILES: OC1=CC2=C3C(CC(N(CCC)CCC)C2)=CC=CC3=C1
Biological Activity: Alentemol (U-68553B free base) is a potent dopamine receptor agonist that can cross the blood-brain barrier. Alentemol inhibits electrical impulse firing and dopamine release of dopamine neurons in the nigrostriatal pathway by activating presynaptic dopamine autoreceptors, without primarily relying on feedback regulation by postsynaptic receptors. Alentemol can be used for research on schizophrenia[1][2][3].
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Alentemol | Alentemol (U-68553B free base) is a potent dopamine receptor agonist that can cross the blood-brain barrier. Alentemol inhibits electrical impulse firing and dopamine release of dopamine neurons in the nigrostriatal pathway by activating presynaptic dopamine autoreceptors, without primarily relying on feedback regulation by postsynaptic receptors. Alentemol can be used for research on schizophrenia. | |||||||||||||||||||||
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References
- [1]. VonVoigtlander PF, et al. Dopamine receptor agonist activity of U-66444B and its enantiomers: evaluation of functional, biochemical, and pharmacokinetic properties. Drug Dev Res. 1989;17:71-81.
- [2]. Borison RL. Recent advances in the pharmacotherapy of schizophrenia. Harv Rev Psychiatry. 1997 Jan-Feb;4(5):255-71.
- [3]. Sershen H, et al. Chronic nicotine-induced changes in dopaminergic system: effect on behavioral response to dopamine agonist. Pharmacol Biochem Behav. 1991 Jun;39(2):545-7.
