116569-08-5
116569-08-5
Chemical Structure
6-Hydroxyisatin
- CAS No.: 116569-08-5
- Formula:C8H5NO3
- Molecular Weight:163.13
IUPAC Name: 6-hydroxyindoline-2,3-dione
InChIKey: OPHRQXIPRXFPJF-UHFFFAOYSA-N
SMILES: O=C1NC2=C(C=CC(O)=C2)C1=O
Biological Activity: 6-Hydroxyisatin is an atrial natriuretic peptide receptor (ANP receptor) inhibitor. 6-Hydroxyisatin exhibits inhibitory activity against ANP-stimulated particulate guanylyl cyclase activity in rat brain cell membranes[1][2].
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6-Hydroxyisatin | 95.86% | 6-Hydroxyisatin is an atrial natriuretic peptide receptor (ANP receptor) inhibitor. 6-Hydroxyisatin exhibits inhibitory activity against ANP-stimulated particulate guanylyl cyclase activity in rat brain cell membranes. | ||||||||||||||||||||
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References
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[1]. Khaled A. Shaaban, et al. Structure elucidation and synthesis of
hydroxylated isatins from Streptomycetes. Z. Naturforsch. 2016; 71(12)b: 1191-1198 - [2]. Medvedev AE, et al. Efficacy of isatin analogues as antagonists of rat brain and heart atrial natriuretic peptide receptors coupled to particulate guanylyl cyclase. Biochem Pharmacol. 1999;57(8):913-915. [Content Brief]
