1184998-16-0
1184998-16-0
Chemical Structure
Tolmetin-d3
- CAS No.: 1184998-16-0
- Formula:C15H12D3NO3
- Molecular Weight:260.30
IUPAC Name: 2-(1-(methyl-d3)-5-(4-methylbenzoyl)-1H-pyrrol-2-yl)acetic acid
InChIKey: UPSPUYADGBWSHF-BMSJAHLVSA-N
SMILES: C(=O)(C=1N(C([2H])([2H])[2H])C(CC(O)=O)=CC1)C2=CC=C(C)C=C2
Biological Activity: Tolmetin-d3 is the deuterium labeled Tolmetin. Tolmetin is an orally active and potent COX inhibitor with IC50s of 0.35 μM and 0.82 μM human COX-1 and COX-2, respectively. Tolmetin is a non-steroidal anti-inflammatory drug (NSAID)[1][2].
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Tolmetin-d3 | Tolmetin-d3 is the deuterium labeled Tolmetin. Tolmetin is an orally active and potent COX inhibitor with IC50s of 0.35 μM and 0.82 μM human COX-1 and COX-2, respectively. Tolmetin is a non-steroidal anti-inflammatory drug (NSAID). | |||||||||||||||||||||
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Tolmetin (Standard) | ≥98% | Tolmetin (Standard) is the analytical standard of Tolmetin. This product is intended for research and analytical applications. Tolmetin is an orally active and potent COX inhibitor with IC50s of 0.35 μM and 0.82 μM human COX-1 and COX-2, respectively. Tolmetin is a non-steroidal anti-inflammatory drug (NSAID). | ||||||||||||||||||||
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Tolmetin | 99.54% | Tolmetin is an orally active and potent COX inhibitor with IC50s of 0.35 μM and 0.82 μM human COX-1 and COX-2, respectively. Tolmetin is a non-steroidal anti-inflammatory drug (NSAID). | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. T D Warner, et al. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7563-8. [Content Brief]
