1189805-15-9
1189805-15-9
Chemical Structure
Proguanil-d4
- CAS No.: 1189805-15-9
- Formula:C11H12D4ClN5
- Molecular Weight:257.76
InChIKey: SSOLNOMRVKKSON-LNFUJOGGSA-N
SMILES: CC(NC(NC(NC1=C(C([2H])=C(Cl)C([2H])=C1[2H])[2H])=N)=N)C
Biological Activity: Proguanil-d4 is the deuterium labeled Proguanil[1]. Proguanil, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil is a dihydrofolate reductase (DHFR) inhibitor[2][3].
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Proguanil-d4 | Proguanil-d4 is the deuterium labeled Proguanil. Proguanil, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil is a dihydrofolate reductase (DHFR) inhibitor. | |||||||||||||||||||||
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Proguanil (Standard) | ≥98% | Proguanil (Standard) is the analytical standard of Proguanil. This product is intended for research and analytical applications. Proguanil, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil is a dihydrofolate reductase (DHFR) inhibitor. | ||||||||||||||||||||
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Proguanil-d6 | Proguanil-d6 is the deuterium labeled Proguanil, which is a prophylactic antimalarial agent. | |||||||||||||||||||||
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Proguanil | 99.84% | Proguanil, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil is a dihydrofolate reductase (DHFR) inhibitor. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Pudney M, et al. Atovaquone and proguanil hydrochloride: a review of nonclinical studies. J Travel Med. 1999 May;6 Suppl 1:S8-12. [Content Brief]
- [3]. Srivastava IK, et al. A mechanism for the synergistic antimalarial action of atovaquone and proguanil. Antimicrob Agents Chemother. 1999 Jun43(6):1334-9. [Content Brief]
