1189971-72-9
1189971-72-9
Chemical Structure
Desethyl chloroquine-d4
- CAS No.: 1189971-72-9
- Formula:C16H18D4ClN3
- Molecular Weight:295.84
IUPAC Name: N4-(7-chloroquinolin-4-yl)-N1-ethylpentane-1,1,2,2-d4-1,4-diamine
InChIKey: MCYUUUTUAAGOOT-AUHPCMSFSA-N
SMILES: CC(NC1=CC=NC2=CC(Cl)=CC=C12)CC([2H])([2H])C([2H])(NCC)[2H]
Biological Activity: Desethyl chloroquine-d4 is the deuterium labeled Desethyl chloroquine. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity[1][2].
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Desethyl chloroquine-d4 | Desethyl chloroquine-d4 is the deuterium labeled Desethyl chloroquine. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity. | |||||||||||||||||||||
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Desethyl chloroquine (Standard) | ≥98% | Desethyl chloroquine (Standard) is the analytical standard of Desethyl chloroquine. This product is intended for research and analytical applications. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity. | ||||||||||||||||||||
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Desethyl chloroquine-d5 | Desethyl chloroquine-d5 is deuterium labeled Desethyl chloroquine. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity. | |||||||||||||||||||||
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Hydroxychloroquine EP impurity D-d5 dihydrochloride | Hydroxychloroquine EP impurity D-d5 (dihydrochloride) is the deuterium labeled Hydroxychloroquine EP impurity D dihydrochloride. | |||||||||||||||||||||
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Desethyl chloroquine | Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity. | |||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Ajayi FO, et al. Comparison of the partitioning in vitro of chloroquine and its desethyl metabolites between the erythrocytes and plasma of healthy subjects and those with falciparum malaria. Afr J Med Med Sci. 1989 Jun;18(2):95-100. [Content Brief]
