1200129-48-1
1200129-48-1
Chemical Structure
GDC-0425
Synonym(s): RG-7602
- CAS No.: 1200129-48-1
- Formula:C18H19N5O
- Molecular Weight:321.38
IUPAC Name: 5-((1-ethylpiperidin-4-yl)oxy)-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile
InChIKey: XEZLBMHDUXSICI-UHFFFAOYSA-N
SMILES: N#CC1=NC=C2C(C3=CC=CN=C3N2)=C1OC4CCN(CC)CC4
Biological Activity: GDC-0425 (RG-7602) is an orally available, highly selective small molecule ChK1 inhibitor. GDC-0425 can be used for the research of various malignancies[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GDC-0425 | 99.39% | GDC-0425 (RG-7602) is an orally available, highly selective small molecule ChK1 inhibitor. GDC-0425 can be used for the research of various malignancies. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.97
HY-19926AGDC-0425 hydrochloride -
Similarity Score 0.48
HY-15883GNE-900 -
Similarity Score 0.46
HY-15882GNE-783 -
Similarity Score 0.46
HY-147017GSK2556286 -
Similarity Score 0.44
HY-103499ZK 93426 hydrochloride -
Similarity Score 0.44
HY-N3640Crenatine -
Similarity Score 0.44
HY-10420ZK-93426 -
Similarity Score 0.44
HY-N16719Picrasidine J -
Similarity Score 0.43
HY-12962NMDA-IN-1 -
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References
- [1]. Xiao Ding, et al. A supported liquid extraction LC-MS/MS method for determination of concentrations of GDC-0425, a small molecule Checkpoint kinase 1 inhibitor, in human plasma. Biomed Chromatogr. 2016 Dec;30(12):1984-1991. [Content Brief]
- [2]. Jeffrey R Infante, et al. Phase I Study of GDC-0425, a Checkpoint Kinase 1 Inhibitor, in Combination with Gemcitabine in Patients with Refractory Solid Tumors. Clin Cancer Res. 2017 May 15;23(10):2423-2432. [Content Brief]
