120128-20-3
Chemical Structure
RG-12525
Synonym(s): NID 525
- CAS No.: 120128-20-3
- Formula:C25H21N5O2
- Molecular Weight:423.47
IUPAC Name: 2-((4-((2-((1H-tetrazol-5-yl)methyl)benzyl)oxy)phenoxy)methyl)quinoline
InChIKey: JELDFLOBXROBFH-UHFFFAOYSA-N
SMILES: C1(COC2=CC=C(OCC3=CC=CC=C3CC4=NN=NN4)C=C2)=NC5=CC=CC=C5C=C1
Biological Activity: RG-12525 is a a specific, competitive and orally effective antagonist of the peptidoleukotrienes, LTC4, LTD4 and LTE4, inhibiting LTC4-, LTD4- and LTE4-inducd guinea pig parenchymal strips contractions, with IC50s of 2.6 nM, 2.5 nM and 7 nM, respectively; RG-12525 is also a peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist with IC50 of appr 60 nM and a potent inhibitor of CYP3A4, with a Ki value of 0.5 µM.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
RG-12525 | 98.31% | RG-12525 is a a specific, competitive and orally effective antagonist of the peptidoleukotrienes, LTC4, LTD4 and LTE4, inhibiting LTC4-, LTD4- and LTE4-inducd guinea pig parenchymal strips contractions, with IC50s of 2.6 nM, 2.5 nM and 7 nM, respectively; RG-12525 is also a peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist with IC50 of appr 60 nM and a potent inhibitor of CYP3A4, with a Ki value of 0.5 µM. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
RG-12525 (Standard) | ≥98% | RG-12525 (Standard) is the analytical standard of RG-12525 (HY-101676). This product is intended for research and analytical applications. RG-12525 is a a specific, competitive and orally effective antagonist of the peptidoleukotrienes, LTC4, LTD4 and LTE4, inhibiting LTC4-, LTD4- and LTE4-inducd guinea pig parenchymal strips contractions, with IC50s of 2.6 nM, 2.5 nM and 7 nM, respectively; RG-12525 is also a peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist with IC50 of appr 60 nM and a potent inhibitor of CYP3A4, with a Ki value of 0.5 μM. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.66
HY-19109RG-7152 -
Similarity Score 0.60
HY-169773Mardepodect precursor -
Similarity Score 0.60
HY-113628AABT-080 free base -
Similarity Score 0.59
HY-113628ABT-080 -
Similarity Score 0.59
HY-120571L-674573 -
Similarity Score 0.58
HY-120945PDE10A-IN-1 -
Similarity Score 0.58
HY-107610SR2640 hydrochloride -
Similarity Score 0.57
HY-136831SR2640 -
Similarity Score 0.57
HY-19139ETH-615 -
Explore the MedChemAI to find more analogs
