120280-33-3
Chemical Structure
Ro 31-7837
- CAS No.: 120280-33-3
- Formula:C17H16N2O2
- Molecular Weight:280.32
IUPAC Name: 2-(6-cyano-2,2-dimethylchroman-4-yl)pyridine 1-oxide
InChIKey: IPASVSRDRRKZCQ-UHFFFAOYSA-N
SMILES: N#CC1=CC=C2C(C(C3=[N+]([O-])C=CC=C3)CC(C)(C)O2)=C1
Biological Activity: APTO-253 (LOR-253) hydrochloride is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 hydrochloride mediates anticancer activity via induction of Kruppel-like factor 4 (KLF4) tumor suppressor. APTO-253 hydrochloride exhibits antiarthritic activity.
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Ro 31-7837 | APTO-253 (LOR-253) hydrochloride is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 hydrochloride mediates anticancer activity via induction of Kruppel-like factor 4 (KLF4) tumor suppressor. APTO-253 hydrochloride exhibits antiarthritic activity. | |||||||||||||||||||||
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Keywords
