1204181-93-0
1204181-93-0
Chemical Structure
AZD1897
- CAS No.: 1204181-93-0
- Formula:C18H23N3O3S
- Molecular Weight:361.46
InChIKey: ULMRMVZQMKZWKJ-MLJKTZRHSA-N
SMILES: O=C(NC/1=O)SC1=C/C2=CC=CC(OC(C)C)=C2N3C[C@H](N)CCC3
Biological Activity: AZD1897 is a PIM1, PIM2, and PIM3 inhibitor with IC50 values of less than 3 nM for these three PIM kinases. AZD1897 exhibits anticancer activity and synergistically inhibits the activity of acute myeloid leukemia (AML) cells in combination with Capivasertib (HY-15431). This synergistic inhibitory effect is achieved through the inhibition of the mTOR and MCL1 pathways[1][2].
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AZD1897 | 99.69% | AZD1897 is a PIM1, PIM2, and PIM3 inhibitor with IC50 values of less than 3 nM for these three PIM kinases. AZD1897 exhibits anticancer activity and synergistically inhibits the activity of acute myeloid leukemia (AML) cells in combination with Capivasertib (HY-15431). This synergistic inhibitory effect is achieved through the inhibition of the mTOR and MCL1 pathways. | ||||||||||||||||||||
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References
- [1]. Dakin LA, et al. Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4599-604. [Content Brief]
- [2]. Meja K, et al. PIM and AKT kinase inhibitors show synergistic cytotoxicity in acute myeloid leukaemia that is associated with convergence on mTOR and MCL1 pathways. Br J Haematol. 2014 Oct;167(1):69-79. [Content Brief]
Keywords
