120533-76-8
Chemical Structure
BML-278
- CAS No.: 120533-76-8
- Formula:C24H25NO4
- Molecular Weight:391.46
IUPAC Name: diethyl 1-benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate
InChIKey: JOHFECBOWRGWJZ-UHFFFAOYSA-N
SMILES: CCOC(C1=CN(C=C(C(OCC)=O)C1C2=CC=CC=C2)CC3=CC=CC=C3)=O
Biological Activity: BML-278 is a SIRT1 activator (EC150: 1 μM). BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in both the paternal and maternal pronucleus. BML-278 improves early embryonic development. BML-278 arrests the cell cycle at the G1/S phase, and reduces senescence in primary human mesenchymal cells. BML-278 reduces tubulin acetylation in U937 cells. BML-278 also increases mitochondrial density in murine C2C12 myoblasts[1][2].
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BML-278 | 98.49% | BML-278 is a SIRT1 activator (EC150: 1 μM). BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in both the paternal and maternal pronucleus. BML-278 improves early embryonic development. BML-278 arrests the cell cycle at the G1/S phase, and reduces senescence in primary human mesenchymal cells. BML-278 reduces tubulin acetylation in U937 cells. BML-278 also increases mitochondrial density in murine C2C12 myoblasts. | ||||||||||||||||||||
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- [1]. Adamkova K, et al. SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9 (H3K9) in the zygotic pronuclei improves porcine embryo development. J Anim Sci Biotechnol. 2017 Nov 1;8:83. [Content Brief]
- [2]. Mai A, et al. Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors. J Med Chem. 2009 Sep 10;52(17):5496-504. [Content Brief]
Keywords
