1207615-74-4
1207615-74-4
Chemical Structure
YTR107
- CAS No.: 1207615-74-4
- Formula:C21H14N4O3
- Molecular Weight:370.36
InChIKey: UGGIKHBVNATJPW-UHFFFAOYSA-N
SMILES: N#CC1=CC=C(CN2C=C(/C=C(C(N3)=O)\C(NC3=O)=O)C4=C2C=CC=C4)C=C1
Biological Activity: YTR107 is a radiation sensitizer. YTR107 binds to nucleophosmin1 (NPM1) and inhibits pentamer formation. YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppresses repair of DNA double strand breaks, and enhances radiosensitization[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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YTR107 | 95.33% | YTR107 is a radiation sensitizer. YTR107 binds to nucleophosmin1 (NPM1) and inhibits pentamer formation. YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppresses repair of DNA double strand breaks, and enhances radiosensitization. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.66
HY-117664PNR-7-02 -
Similarity Score 0.59
HY-184271SphK1-IN-5 -
Similarity Score 0.57
HY-16662Oncrasin-1 -
Similarity Score 0.57
HY-176835PNR-3-80 -
Similarity Score 0.56
HY-176836PNR-3-82 -
Similarity Score 0.55
HY-168468SKLB102 -
Similarity Score 0.53
HY-122315Oncrasin-60 -
Similarity Score 0.53
HY-116074FUB-PB-22 3-carboxyindole metabolite -
Similarity Score 0.52
HY-W0301202-(1-(4-Fluorobenzyl)-1H-indol-3-yl)acetic acid -
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References
- [1]. Sekhar KR, et al. The novel chemical entity YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppressing repair of DNA double-strand breaks and enhancing radiosensitization. Clin Cancer Res. 2011 Oct 15;17(20):6490-9. [Content Brief]
- [2]. Traver G, et al. Targeting NPM1 in irradiated cells inhibits NPM1 binding to RAD51, RAD51 foci formation and radiosensitizes NSCLC. Cancer Lett. 2021 Mar 1;500:220-227. [Content Brief]
