1213669-91-0
Chemical Structure
L-838417-d9
- CAS. Nr.: 1213669-91-0
- Formula:C19H10D9F2N7O
- Molecular Weight:408.45
IUPAC Name: 3-(2,5-difluorophenyl)-6-((1-methyl-1H-1,2,4-triazol-5-yl)methoxy)-7-(2-(methyl-d3)propan-2-yl-1,1,1,3,3,3-d6)-[1,2,4]triazolo[4,3-b]pyridazine
InChIKey: BQDUNOMMYOKHEP-GQALSZNTSA-N
SMILES: CN1N=CN=C1COC(C(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=C2)=NN3C2=NN=C3C4=CC(F)=CC=C4F
Biological Activity: L-838417-d9 is the deuterium labeled L-838417 (HY-W009009). L-838417 is a selective partial agonist at the α2, α3 and α5 subtypes of the GABAA receptor and an antagonist at the α1, with binding Ki values of 0.79 nM, 0.67 nM, 1.67 nM, 267 nM, 2.25 nM and 2183 nM for α1β3γ2, α2β3γ2, α3β3γ2, α4β3γ2, α5β3γ2 and α6β3γ2. L-838417 has anti-anxiety activity[1].
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L-838417-d9 | 99.74% | L-838417-d9 is the deuterium labeled L-838417 (HY-W009009). L-838417 is a selective partial agonist at the α2, α3 and α5 subtypes of the GABAA receptor and an antagonist at the α1, with binding Ki values of 0.79 nM, 0.67 nM, 1.67 nM, 267 nM, 2.25 nM and 2183 nM for α1β3γ2, α2β3γ2, α3β3γ2, α4β3γ2, α5β3γ2 and α6β3γ2. L-838417 has anti-anxiety activity. | ||||||||||||||||||||
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L-838417 (Standard) | ≥98% | L-838417 (Standard) is the analytical standard of L-838417 (HY-W009009). This product is intended for research and analytical applications. L-838417 is a selective partial agonist at the α2, α3 and α5 subtypes of the GABAA receptor and an antagonist at the α1, with binding Ki values of 0.79 nM, 0.67 nM, 1.67 nM, 267 nM, 2.25 nM and 2183 nM for α1β3γ2, α2β3γ2, α3β3γ2, α4β3γ2, α5β3γ2 and α6β3γ2. L-838417 has anti-anxiety activity. | ||||||||||||||||||||
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L-838417 | 98.73% | L-838417 is a selective partial agonist at the α2, α3 and α5 subtypes of the GABAA receptor and an antagonist at the α1, with binding Ki values of 0.79 nM, 0.67 nM, 1.67 nM, 267 nM, 2.25 nM and 2183 nM for α1β3γ2, α2β3γ2, α3β3γ2, α4β3γ2, α5β3γ2 and α6β3γ2. L-838417 has anti-anxiety activity. | ||||||||||||||||||||
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Similarity Score 0.79
HY-101640TPA 023 -
Similarity Score 0.70
HY-101869RMK-0343 (Standard) -
Similarity Score 0.64
HY-101869MK-0343 -
Similarity Score 0.58
HY-100370MRK-016 -
Similarity Score 0.48
HY-116622α5IA -
Similarity Score 0.47
HY-U0032511β-HSD1-IN-1 -
Similarity Score 0.46
HY-16032Akt1-IN-2 -
Similarity Score 0.46
HY-120496Clofutriben -
Similarity Score 0.46
HY-134562PF-06371900 -
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References
- [1]. Hofmann M, et al. Assessment of the effects of NS11394 and L-838417, α2/3 subunit-selective GABA(A) [corrected] receptor-positive allosteric modulators, in tests for pain, anxiety, memory and motor function [published correction appears in Behav Pharmacol. 2013 Apr;24(2):153]. Behav Pharmacol. 2012;23(8):790-801. [Content Brief]
