1215313-19-1
1215313-19-1
Chemical Structure
B-Raf IN 8
- CAS No.: 1215313-19-1
- Formula:C18H17N3O2
- Molecular Weight:307.35
IUPAC Name: (E)-6-(4-((4-methoxybenzylidene)amino)phenyl)-4,5-dihydropyridazin-3(2H)-one
InChIKey: YTISYWXNCFXKDO-XDHOZWIPSA-N
SMILES: O=C1CCC(C2=CC=C(/N=C/C3=CC=C(OC)C=C3)C=C2)=NN1
Biological Activity: B-Raf IN 8 (compound 7g) is a potent B-Raf inhibitor, with an IC50 of 70.65 nM. B-Raf IN 8 exhibits antitumor activity against hepatocellular carcinoma (HEPG-2), colon carcinoma (HCT-116), mammary gland (MCF-7) and human prostate cancer (PC-3) cells, with IC50 values of 9.78, 13.78, 18.52 and 29.85 µM[1].
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B-Raf IN 8 | B-Raf IN 8 (compound 7g) is a potent B-Raf inhibitor, with an IC50 of 70.65 nM. B-Raf IN 8 exhibits antitumor activity against hepatocellular carcinoma (HEPG-2), colon carcinoma (HCT-116), mammary gland (MCF-7) and human prostate cancer (PC-3) cells, with IC50 values of 9.78, 13.78, 18.52 and 29.85 µM. | |||||||||||||||||||||
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