1216630-06-6
Chemical Structure
Medetomidine-13C,d3 hydrochloride
Synonym(s): MPV785-13C,d3
- CAS No.: 1216630-06-6
- Formula:C1213CH14D3ClN2
- Molecular Weight:240.75
IUPAC Name: 5-(1-(2,3-dimethylphenyl)ethyl-2-13C-2,2,2-d3)-1H-imidazole hydrochloride
InChIKey: VPNGEIHDPSLNMU-RWALGPICSA-N
SMILES: CC1=C(C)C(C(C2=CN=CN2)[13C]([2H])([2H])[2H])=CC=C1.Cl
Biological Activity: Medetomidine-13C,d3 (hydrochloride) is a deuterated labeled Medetomidine (hydrochloride)[1]. Medetomidine hydrochloride is an orally active α2-adrenoceptor agonist (Ki: 1.08 nM). Medetomidine hydrochloride has sedative and analgesic effects. Medetomidine hydrochloride can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels[2][3][4][5].
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Medetomidine-13C,d3 hydrochloride | 99.48% | Medetomidine-13C,d3 (hydrochloride) is a deuterated labeled Medetomidine (hydrochloride). Medetomidine hydrochloride is an orally active α2-adrenoceptor agonist (Ki: 1.08 nM). Medetomidine hydrochloride has sedative and analgesic effects. Medetomidine hydrochloride can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels. | ||||||||||||||||||||
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Medetomidine hydrochloride (Standard) | ≥98% | Medetomidine (hydrochloride) (Standard) is the analytical standard of Medetomidine (hydrochloride). This product is intended for research and analytical applications. Medetomidine hydrochloride is an orally active α2-adrenoceptor agonist (Ki: 1.08 nM). Medetomidine hydrochloride has sedative and analgesic effects. Medetomidine hydrochloride can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels. | ||||||||||||||||||||
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Medetomidine-d3 hydrochloride | Medetomidine-d3 (hydrochloride) is the deuterium labeled Medetomidine hydrochloride. Medetomidine hydrochloride is an agonist of adrenergic alpha-2 receptor. | |||||||||||||||||||||
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Medetomidine hydrochloride | 99.94% | Medetomidine hydrochloride is an orally active α2-adrenoceptor agonist (Ki: 1.08 nM). Medetomidine hydrochloride has sedative and analgesic effects. Medetomidine hydrochloride can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [3]. Kallio A, et al. Acute effects of medetomidine, a selective alpha 2-adrenoceptor agonist, on anterior pituitary hormone and cortisol secretion in man. Acta Endocrinol (Copenh). 1988 Sep;119(1):11-5. [Content Brief]
- [4]. R Virtanen, et al. Characterization of the selectivity, specificity and potency of medetomidine as an a2-adrenoceptor agonist. [Content Brief]
- [5]. O. B. Ansah, et al. Comparing oral and intramuscular administration of medetomidine in cats.
