1225041-97-3
Chemical Structure
BIIB021 mesylate
Synonym(s): CNF2024 mesylate
- CAS. Nr.: 1225041-97-3
- Formula:C15H19ClN6O4S
- Molecular Weight:414.87
IUPAC Name: 6-chloro-9-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-9H-purin-2-amine methanesulfonate
InChIKey: QQYUAUPJJLOCHU-UHFFFAOYSA-N
SMILES: O=S(O)(C)=O.ClC1=NC(N)=NC2=C1N=CN2CC3=NC=C(C)C(OC)=C3C
Biological Activity: BIIB021 (CNF2024) mesylate is the mesylate of BIIB021 (HY-10212). BIIB021 is an orally active Hsp90 inhibitor. BIIB021 inhibits the proliferation of chronic myeloid leukemia (CML) cells, with IC50 values of K562, K562/G, 32Dp210, and 32Dp210-T315I cells are 513.99, 603.53, 110.08, and 148.07 nM, respectively. BIIB021 degrades BCR-ABL protein and inhibits the β-catenin/c-Myc pathway. BIIB021 can also induce autophagy in CML cells. BIIB021 can be used for the research of CML[1].
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BIIB021 mesylate | BIIB021 (CNF2024) mesylate is the mesylate of BIIB021 (HY-10212). BIIB021 is an orally active Hsp90 inhibitor. BIIB021 inhibits the proliferation of chronic myeloid leukemia (CML) cells, with IC50 values of K562, K562/G, 32Dp210, and 32Dp210-T315I cells are 513.99, 603.53, 110.08, and 148.07 nM, respectively. BIIB021 degrades BCR-ABL protein and inhibits the β-catenin/c-Myc pathway. BIIB021 can also induce autophagy in CML cells. BIIB021 can be used for the research of CML. | |||||||||||||||||||||
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