122853-28-5
122853-28-5
Chemical Structure
5-Methoxyluzindole
- CAS No.: 122853-28-5
- Formula:C20H22N2O2
- Molecular Weight:322.40
InChIKey: MUQOTEHRXIKHKR-UHFFFAOYSA-N
SMILES: O=C(C)NCCC1=C(CC2=CC=CC=C2)NC3=C1C=C(C=C3)OC
Biological Activity: 5-Methoxyluzindole is a partial Melatonin Receptor agonist with a high-affinity Ki value of 3 pM in hamsters. 5-Methoxyluzindole inhibits the binding of radioligands to melatonin receptors in median eminence/pars tuberalis membranes. 5-Methoxyluzindole mimics the in vivo antigonadal and body weight-reducing effects of melatonin in hamsters. 5-Methoxyluzindole can be used in research related to melatonin receptor-mediated diseases[1][2][3].
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5-Methoxyluzindole | 5-Methoxyluzindole is a partial Melatonin Receptor agonist with a high-affinity Ki value of 3 pM in hamsters. 5-Methoxyluzindole inhibits the binding of radioligands to melatonin receptors in median eminence/pars tuberalis membranes. 5-Methoxyluzindole mimics the in vivo antigonadal and body weight-reducing effects of melatonin in hamsters. 5-Methoxyluzindole can be used in research related to melatonin receptor-mediated diseases. | |||||||||||||||||||||
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References
- [1]. Mao L, et al. In vitro and in vivo antitumor activity of melatonin receptor agonists. Journal of pineal research. 2010 Oct;49(3):210-21.
- [2]. Duncan MJ, et al. Effects of melatonin agonists and antagonists on reproduction and body weight in the Siberian hamster. Journal of pineal research. 1990;9(4):231-42.
- [3]. Popovska-Gorevski M. Pharmacological characteristics and apparent efficacy of melatonin ligands at the human and the mouse MT1 and MT2 melatonin receptors. 2014.
