5-Methoxyluzindole
5-Methoxyluzindole is a partial Melatonin Receptor agonist with a high-affinity Ki value of 3 pM in hamsters. 5-Methoxyluzindole inhibits the binding of radioligands to melatonin receptors in median eminence/pars tuberalis membranes. 5-Methoxyluzindole mimics the in vivo antigonadal and body weight-reducing effects of melatonin in hamsters. 5-Methoxyluzindole can be used in research related to melatonin receptor-mediated diseases.
For research use only. We do not sell to patients.
- CAS No.: 122853-28-5
- Formula: C20H22N2O2
- Molecular Weight:322.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
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MT2 |
MT1 |
In Vitro
5-Methoxyluzindole is a potent inhibitor of 2-[125I]-iodomelatonin binding in Siberian hamster median eminence/pars tuberalis membranes, with a high-affinity Ki of 3 pM and a low-affinity Ki of 4 nM[2].
5-Methoxyluzindole shows 170-fold higher affinity for hMT2 than for hMT1 in transiently transfected COS-7 cells, with a 21-fold selectivity difference between mMT1/mMT2[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
5-Methoxyluzindole (10 mg/kg; injection; daily; 14 days) does not prevent short-photoperiod-induced testicular regression in juvenile Siberian hamsters[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Phodopus sungorus sungorus (male, 3-5 months old)[2]
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Dosage:10 mg/kg
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Administration:injection; daily; 7 weeks
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Result:Produced a profound decrease in testes weight and a lower body weight compared with vehicle-treated hamsters.
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Animal Model:Phodopus sungorus sungorus (male, 18-day-old juveniles)[2]
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Dosage:10 mg/kg
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Administration:injection; daily; 14 days
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Result:Exposed to short photoperiod, hamsters exhibited lower testes weights than long-photoperiod controls regardless of drug administration.
Did not block the inhibitory effect of endogenous Melatonin or affect testicular regression.
Chemical Information
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CAS No. 122853-28-5
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Molecular Weight 322.40
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Formula C20H22N2O2
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SMILES
O=C(C)NCCC1=C(CC2=CC=CC=C2)NC3=C1C=C(C=C3)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
5-Methoxyluzindole Related Classifications
HY-187980 Related Classifications
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