1239358-85-0
1239358-85-0
Chemical Structure
Ilginatinib hydrochloride
Synonym(s): NS-018 hydrochloride
- CAS No.: 1239358-85-0
- Formula:C21H21ClFN7
- Molecular Weight:425.89
IUPAC Name: (S)-N2-(1-(4-fluorophenyl)ethyl)-4-(1-methyl-1H-pyrazol-4-yl)-N6-(pyrazin-2-yl)pyridine-2,6-diamine hydrochloride
InChIKey: XFNVGPXGVAXXSH-UQKRIMTDSA-N
SMILES: [H]Cl.CN1N=CC(C2=CC(N[C@H](C3=CC=C(F)C=C3)C)=NC(NC4=NC=CN=C4)=C2)=C1
Biological Activity: Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable JAK2 inhibitor, with an IC50 of 0.72 nM, 46-, 54-, and 31-fold selectivity for JAK2 over JAK1 (IC50, 33 nM), JAK3 (IC50, 39 nM), and Tyk2 (IC50, 22 nM).
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ilginatinib hydrochloride | 98.92% | Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable JAK2 inhibitor, with an IC50 of 0.72 nM, 46-, 54-, and 31-fold selectivity for JAK2 over JAK1 (IC50, 33 nM), JAK3 (IC50, 39 nM), and Tyk2 (IC50, 22 nM). | ||||||||||||||||||||
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