1240287-64-2
Chemical Structure
STING-IN-20
- CAS No.: 1240287-64-2
- Formula:C27H30N6O3
- Molecular Weight:486.57
InChIKey: NNYJHOWCICJDAM-UHFFFAOYSA-N
SMILES: O=C(C)C(C=C1)=CC=C1N(CC2)CCN2C(C3CCN(C(C4=CC(C5=CC=CC=N5)=NN4)=O)CC3)=O
Biological Activity: STING-IN-20 is an orally active STING inhibitor with a Kd of 0.699 μM. STING-IN-20 binds to the orthosteric binding pocket of STING CTD and inhibits cGAMP-induced STING activation, oligomerization, and downstream TBK1/IRF3 phosphorylation. STING-IN-20 inhibits NLRP3-related pyroptosis and IL-1β expression, restores autophagic flux and phagocytic capacity, attenuates mitochondrial depolarization, and reduces macrophage-to-β cell mitochondrial transfer in macrophages. STING-IN-20 can be used for research on severe acute pancreatitis[1].
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STING-IN-20 | STING-IN-20 is an orally active STING inhibitor with a Kd of 0.699 μM. STING-IN-20 binds to the orthosteric binding pocket of STING CTD and inhibits cGAMP-induced STING activation, oligomerization, and downstream TBK1/IRF3 phosphorylation. STING-IN-20 inhibits NLRP3-related pyroptosis and IL-1β expression, restores autophagic flux and phagocytic capacity, attenuates mitochondrial depolarization, and reduces macrophage-to-β cell mitochondrial transfer in macrophages. STING-IN-20 can be used for research on severe acute pancreatitis. | |||||||||||||||||||||
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