1242443-29-3
1242443-29-3
Chemical Structure
VU0364289
- CAS No.: 1242443-29-3
- Formula:C20H21N3O2
- Molecular Weight:335.40
IUPAC Name: 2-(4-(2-(benzyloxy)acetyl)piperazin-1-yl)benzonitrile
InChIKey: LTPGKAICNBCBPT-UHFFFAOYSA-N
SMILES: N#CC1=CC=CC=C1N2CCN(CC2)C(COCC3=CC=CC=C3)=O
Biological Activity: VU0364289 is a highly selective mGlu5 positive allosteric modulator (PAM) (binds to the MPEP (HY-14609A) site), with an EC50 of 1.6 μM. VU0364289 shows excellent central nervous system penetration. VU0364289 can reverse amphetamine-induced hyperlocomotion in a dose-dependent manner, which can be used for schizophrenia and other psychiatric research[1][2][3].
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VU0364289 | 99.52% | VU0364289 is a highly selective mGlu5 positive allosteric modulator (PAM) (binds to the MPEP (HY-14609A) site), with an EC50 of 1.6 μM. VU0364289 shows excellent central nervous system penetration. VU0364289 can reverse amphetamine-induced hyperlocomotion in a dose-dependent manner, which can be used for schizophrenia and other psychiatric research. | ||||||||||||||||||||
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References
- [1]. Gregory KJ, et al. N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement. J Pharmacol Exp Ther. 2013 Nov;347(2):438-57. [Content Brief]
- [2]. Ya Zhou, et al. Discovery of N-Aryl Piperazines as Selective mGluR5Potentiators with Improved In Vivo Utility. ACS medicinal chemistry letters, 2010, 1(8): 433-438.
- [3]. Psychosis Models[M]//Melatonin, Neuroprotective Agents and Antidepressant Therapy. Springer, New Delhi, 2016: 731-750.
