129700-44-3
129700-44-3
Chemical Structure
Ac-Atovaquone
- CAS No.: 129700-44-3
- Formula:C24H21ClO4
- Molecular Weight:408.87
SMILES: O=C1C([C@H]2CC[C@H](C3=CC=C(Cl)C=C3)CC2)=C(OC(C)=O)C(C4=CC=CC=C41)=O
Biological Activity: Ac-Atovaquone is a potent cytochrome bc1 inhibitor and also is an ester-linked acetyl derivative of atovaquone (HY-13832). Ac-Atovaquone has the potential for the research of malaria[1][1][2].
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Ac-Atovaquone | Ac-Atovaquone is a potent cytochrome bc1 inhibitor and also is an ester-linked acetyl derivative of atovaquone (HY-13832). Ac-Atovaquone has the potential for the research of malaria. | |||||||||||||||||||||
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References
- [1]. Siqueira-Neto JL, et al. Antimalarial drug discovery: progress and approaches. Nat Rev Drug Discov. 2023 Oct;22(10):807-826. doi: 10.1038/s41573-023-00772-9. Epub 2023 Aug 31. Erratum in: Nat Rev Drug Discov. 2024 Nov;23(11):880.
- [2]. El Gaaloul M, et al. Chemoprevention of malaria with long-acting oral and injectable drugs: an updated target product profile. Malar J. 2024 Oct 18;23(1):315. [Content Brief]
Keywords
