129787-65-1
Chemical Structure
Rhod-2 triammonium
- CAS No.: 129787-65-1
- Formula:C39H49N7O11
- Molecular Weight:791.85
IUPAC Name: N-(2-(2-(2-(bis(carboxymethyl)amino)phenoxy)ethoxy)-4-(3,6-bis(dimethylamino)xanthylium-9-yl)phenyl)-N-(carboxymethyl)glycinate, triammonia salt
InChIKey: ICQGPMAGDCHPQE-UHFFFAOYSA-N
SMILES: O=C(CN(CC(O)=O)C1=C(OCCOC2=C(N(CC(O)=O)CC(O)=O)C=CC=C2)C=C(C3=C4C=CC(N(C)C)=CC4=[O+]C5=C3C=CC(N(C)C)=C5)C=C1)[O-].N.N.N
Biological Activity: Rhod-2 triammonium is a cell impermeant, red fluorescent calcium indicator. Rhod-2 triammonium exhibits a significant shift in fluorescence intensity upon calcium binding (ex max=549 nm; calcium-free v. ex/em max=552/581 nm; calcium-bound). Unlike the UV-excitable indicators Fura-2 and Indo-1 (HY-D0121), there is no accompanying spectral shift[1][2].
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Rhod-2 triammonium | Rhod-2 triammonium is a cell impermeant, red fluorescent calcium indicator. Rhod-2 triammonium exhibits a significant shift in fluorescence intensity upon calcium binding (ex max=549 nm; calcium-free v. ex/em max=552/581 nm; calcium-bound). Unlike the UV-excitable indicators Fura-2 and Indo-1 (HY-D0121), there is no accompanying spectral shift. | |||||||||||||||||||||
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- [1]. Minta, et al. Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores. J. Biol. Chem. 264(14), 8171-8178 (1989).
- [2]. Maxwell JT, et al. A novel mechanism of tandem activation of ryanodine receptors by cytosolic and SR luminal Ca2+ during excitation-contraction coupling in atrial myocytes. J Physiol. 2017 Jun 15;595(12):3835-3845. [Content Brief]
Keywords
