130400-16-7
130400-16-7
Chemical Structure
447C88
- CAS No.: 130400-16-7
- Formula:C27H38F2N2O
- Molecular Weight:444.60
IUPAC Name: 1-(2,4-difluoro-6-(4-neopentylphenethyl)phenyl)-3-heptylurea
InChIKey: XWWXRQIQZOTQGF-UHFFFAOYSA-N
SMILES: O=C(NCCCCCCC)NC1=C(F)C=C(F)C=C1CCC2=CC=C(CC(C)(C)C)C=C2
Biological Activity: 447C88 is an acyl-coenzyme A cholesterol acyltransferase (ACAT) inhibitor with an IC50 of 23 nM. 447C88 can reduce plasma cholesterol levels and can be used in the research of endocrine and metabolic diseases such as hyperlipidemia[1][2].
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447C88 | 447C88 is an acyl-coenzyme A cholesterol acyltransferase (ACAT) inhibitor with an IC50 of 23 nM. 447C88 can reduce plasma cholesterol levels and can be used in the research of endocrine and metabolic diseases such as hyperlipidemia. | |||||||||||||||||||||
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References
- [1]. Fraser IJ, et al. Determination of the acylcoenzyme A cholesterol acyltransferase inhibitor 447C88 in plasma using gas chromatography-mass spectrometry and liquid chromatography atmospheric pressure chemical ionisation tandem mass spectrometry. J Chromatogr B Biomed Appl. 1995 Jan 20;663(2):275-87. [Content Brief]
- [2]. Peck RW, et al. The tolerability, pharmacokinetics and lack of effect on plasma cholesterol of 447C88, an AcylCoA: Cholesterol Acyl Transferase (ACAT) inhibitor with low bioavailability, in healthy volunteers. Eur J Clin Pharmacol. 1995;49(3):243-9. [Content Brief]
Keywords
