131-56-6
Chemical Structure
2,4′-Dihydroxybenzophenone
Synonym(s): Ultraviolet absorber UV-0
- CAS No.: 131-56-6
- Formula:C13H10O3
- Molecular Weight:214.22
IUPAC Name: (2,4-dihydroxyphenyl)(phenyl)methanone
InChIKey: ZXDDPOHVAMWLBH-UHFFFAOYSA-N
SMILES: OC1=CC(O)=C(C(C2=CC=CC=C2)=O)C=C1
Biological Activity: 2,4′-Dihydroxybenzophenone (Ultraviolet absorber UV-0) occupies the hydrophobic pocket of MD2 and blocks the dimerization of TLR4. 2,4′-Dihydroxybenzophenone inhibits the LPS induced mtROS production, and LPS induced inflammatory response by downregulating pro-inflammatory mediators and decreasing the expression of MyD88, p-IRAK4, and NF-κB. 2,4′-Dihydroxybenzophenone is also a UV absorber[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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2,4′-Dihydroxybenzophenone | 98.00% | 2,4′-Dihydroxybenzophenone (Ultraviolet absorber UV-0) occupies the hydrophobic pocket of MD2 and blocks the dimerization of TLR4. 2,4′-Dihydroxybenzophenone inhibits the LPS induced mtROS production, and LPS induced inflammatory response by downregulating pro-inflammatory mediators and decreasing the expression of MyD88, p-IRAK4, and NF-κB. 2,4′-Dihydroxybenzophenone is also a UV absorber. | ||||||||||||||||||||
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2,4′-Dihydroxybenzophenone (Standard) | ≥98% | 2,4′-Dihydroxybenzophenone (Standard) is the analytical standard of 2,4′-Dihydroxybenzophenone. This product is intended for research and analytical applications. 2,4′-Dihydroxybenzophenone (Ultraviolet absorber UV-0) occupies the hydrophobic pocket of MD2 and blocks the dimerization of TLR4. 2,4′-Dihydroxybenzophenone inhibits the LPS induced mtROS production, and LPS induced inflammatory response by downregulating pro-inflammatory mediators and decreasing the expression of MyD88, p-IRAK4, and NF-κB. 2,4′-Dihydroxybenzophenone is also a UV absorber. | ||||||||||||||||||||
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2,4-Dihydroxybenzophenone-13C6 | 2,4-Dihydroxybenzophenone-13C6 (Ultraviolet absorber UV-0-13C6) is the 13C- and deuterium labeled (2,4-Dihydroxyphenyl)(phenyl)methanone. | |||||||||||||||||||||
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2,4′-Dihydroxybenzophenone-d5 | (2,4-Dihydroxyphenyl)(phenyl)methanone-d5 is the deuterium labeled (2,4-Dihydroxyphenyl)(phenyl)methanone. | |||||||||||||||||||||
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- [1]. Kavinda MHD, et al. 2,4'-Dihydroxybenzophenone: A Promising Anti-Inflammatory Agent Targeting Toll-like Receptor 4/Myeloid Differentiation Factor 2-Mediated Mitochondrial Reactive Oxygen Species Production during Lipopolysaccharide-Induced Systemic Inflammation. ACS Pharmacol Transl Sci. 2024 Apr 27;7(5):1320-1334. [Content Brief]
- [2]. Fang Z, et al. Effect of Substituent Groups on the Strength of Intramolecular Hydrogen Bonds in 2,4-Dihydroxybenzophenone UV Absorbers. Molecules. 2023 Jun 27;28(13):5017. [Content Brief]
