13100-69-1
Chemical Structure
5,6-Epoxyretinoic acid
Synonym(s): 5,6-epoxy atRA; 5,6-epoxy RA
- CAS No.: 13100-69-1
- Formula:C20H28O3
- Molecular Weight:316.43
IUPAC Name: (2E,4E,6E,8E)-3,7-dimethyl-9-(2,2,6-trimethyl-7-oxabicyclo[4.1.0]heptan-1-yl)nona-2,4,6,8-tetraenoic acid
InChIKey: KEEHJLBAOLGBJZ-WEDZBJJJSA-N
SMILES: CC12OC1(C(C)(CCC2)C)/C=C/C(C)=C/C=C/C(C)=C/C(O)=O
Biological Activity: all-trans-5,6-epoxy Retinoic acid (5,6-epoxy RA) is an agonist of all isoforms of the retinoic acid receptor (RAR; EC50s=77, 35, and 4 nM for RARα, RARβ, and RARγ, respectively). 5,6-epoxy RA (1 μM) also induces growth arrest of MCF-7 and NB4 cells in vitro. It is a natural metabolite of all-trans retinoic acid, which is a metabolite of vitamin A.
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5,6-Epoxyretinoic acid | all-trans-5,6-epoxy Retinoic acid (5,6-epoxy RA) is an agonist of all isoforms of the retinoic acid receptor (RAR; EC50s=77, 35, and 4 nM for RARα, RARβ, and RARγ, respectively). 5,6-epoxy RA (1 μM) also induces growth arrest of MCF-7 and NB4 cells in vitro. It is a natural metabolite of all-trans retinoic acid, which is a metabolite of vitamin A. | |||||||||||||||||||||
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Keywords
