131774-53-3
Chemical Structure
Longestin
Synonym(s): KS-505a
- CAS No.: 131774-53-3
- Formula:C61H88O17
- Molecular Weight:1093.34
IUPAC Name: (1R,2S,4R,4aR,4bS,6R,6aS,6bS,8aR,8bS,10aS,17aS,17bR,19aS,19bR,21aS,21bS,23aR)-2-(((2R,3R,4S,5S,6S)-6-carboxy-4,5-dihydroxy-3-methoxytetrahydro-2H-pyran-2-yl)oxy)-14-hydroxy-8a,10a-bis(hydroxymethyl)-14-(3-methoxy-3-oxopropyl)-1,4,4a,6,6a,17b,19b,21b-octam
InChIKey: DBIAGVXGCNWASW-PFGNFHTFSA-N
SMILES: OC[C@@]12[C@]3([H])[C@]([C@@]4([H])[C@](CC3)(OC5=CC=C(C(O)(OC6=O)CCC(OC)=O)C6=C5C4)CO)(CC[C@@]1([H])[C@]7([C@]([C@@]8([C@@]([C@]9([C@]([C@@]%10([C@@]([C@](C)([C@H](C[C@H]%10C)O[C@H]%11[C@@H]([C@H]([C@@H]([C@H](O%11)C(O)=O)O)O)OC)C(O)=O)([H])CC9)C)([H])C[C@H]8C)C)([H])CC7)C)([H])CC2)C)C
Biological Activity: Longestin (KS-505a) is a specific inhibitor of phosphodiesterase with antitrypanosomal activity, which is derived from Streptomyces argenteolus. Longestin is promising for research of anti-amnesia agent[1][2].
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Longestin | Longestin (KS-505a) is a specific inhibitor of phosphodiesterase with antitrypanosomal activity, which is derived from Streptomyces argenteolus. Longestin is promising for research of anti-amnesia agent. | |||||||||||||||||||||
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References
- [1]. Ozaki T, et al. Enzymatic Formation of a Skipped Methyl-Substituted Octaprenyl Side Chain of Longestin (KS-505a): Involvement of Homo-IPP as a Common Extender Unit. Angew Chem Int Ed Engl. 2018 May 28;57(22):6629-6632. [Content Brief]
- [2]. Hayashi Y, et al. Cloning of the gene cluster responsible for biosynthesis of KS-505a (longestin), a unique tetraterpenoid. Biosci Biotechnol Biochem. 2007 Dec;71(12):3072-81. [Content Brief]
