132018-32-7
132018-32-7
Chemical Structure
Aminogenistein
- CAS No.: 132018-32-7
- Formula:C15H11NO3
- Molecular Weight:253.26
IUPAC Name: 2-(4-aminophenyl)-6-hydroxy-4H-chromen-4-one
InChIKey: YBQRUOMICVULNM-UHFFFAOYSA-N
SMILES: O=C1C=C(OC2=CC=C(O)C=C12)C=3C=CC(N)=CC3
Biological Activity: Aminogenistein is a p56lck inhibitor with a 1.2 μM IC50. Aminogenistein inhibits production of Aβ1-40 and Aβ1-42 peptides. Aminogenistein induces accumulation of APP-CTFα and APP-CTFβ, indicating γ-secretase cleavage inhibition. Aminogenistein can be used for the research of alzheimer's disease[1][2].
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Aminogenistein | Aminogenistein is a p56lck inhibitor with a 1.2 μM IC50. Aminogenistein inhibits production of Aβ1-40 and Aβ1-42 peptides. Aminogenistein induces accumulation of APP-CTFα and APP-CTFβ, indicating γ-secretase cleavage inhibition. Aminogenistein can be used for the research of alzheimer's disease. | |||||||||||||||||||||
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References
- [1]. Cushman M, et al. Synthesis and biochemical evaluation of a series of aminoflavones as potential inhibitors of protein-tyrosine kinases p56lck, EGFr, and p60v-src. J Med Chem. 1994 Sep 30;37(20):3353-62. [Content Brief]
- [2]. Paris D, et al. Flavonoids lower Alzheimer's Aβ production via an NFκB dependent mechanism. Bioinformation. 2011;6(6):229-236. [Content Brief]
