1332290-68-2
Chemical Structure
NMac1
- CAS No.: 1332290-68-2
- Formula:C24H28O4
- Molecular Weight:380.48
IUPAC Name: (E)-2-(3,4-dimethoxystyryl)-3',4'-dimethoxy-1,2,3,4-tetrahydro-1,1'-biphenyl
InChIKey: PHLVYOUORNHOLU-PKNBQFBNSA-N
SMILES: COC1=CC(/C=C/C2C(C3=CC=C(OC)C(OC)=C3)C=CCC2)=CC=C1OC
Biological Activity: NMac1 is an orally active Nm23/NDPK activator. NMac1 directly binds to Nm23-H1 and activates the NDPK activity of recombinant Nm23-H1 with an EC50 of 10.7 uM. NMac1 induces AMPK activation and inhibits mTOR and ERK, leading to mitochondrial OXPHOS dysregulation and suppressing mitochondrial ROS production, which in turn induces mitochondrial dysfunction in MDA-MB-231 cells. NMac1 inhibits Complex I activity and suppresses changes in morphology and actin cytoskeleton organization following Rac1 activation in MDA-MB-231 cells. NMac1 inhibits tumor invasion, migration and metastasis. NMac1 is useful for studying metastatic tumors, such as breast cancer. NMac1 can be isolated from the ginger cassumunar Roxb[1][2].
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NMac1 | NMac1 is an orally active Nm23/NDPK activator. NMac1 directly binds to Nm23-H1 and activates the NDPK activity of recombinant Nm23-H1 with an EC50 of 10.7 uM. NMac1 induces AMPK activation and inhibits mTOR and ERK, leading to mitochondrial OXPHOS dysregulation and suppressing mitochondrial ROS production, which in turn induces mitochondrial dysfunction in MDA-MB-231 cells. NMac1 inhibits Complex I activity and suppresses changes in morphology and actin cytoskeleton organization following Rac1 activation in MDA-MB-231 cells. NMac1 inhibits tumor invasion, migration and metastasis. NMac1 is useful for studying metastatic tumors, such as breast cancer. NMac1 can be isolated from the ginger cassumunar Roxb. | |||||||||||||||||||||
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- [1]. Lee JJ,et al. Small molecule activator of Nm23/NDPK as an inhibitor of metastasis. Sci Rep. 2018 Jul 19;8(1):10909. [Content Brief]
- [2]. Kim B, et al. Nm23-H1 activator phenylbutenoid dimer exerts cytotoxic effects on metastatic breast cancer cells by inducing mitochondrial dysfunction only under glucose starvation. Sci Rep. 2021 Dec 7;11(1):23549. [Content Brief]
Keywords
