133718-29-3
133718-29-3
Chemical Structure
Revizinone
Synonym(s): R80122
- CAS No.: 133718-29-3
- Formula:C26H29N5O3
- Molecular Weight:459.55
IUPAC Name: (E)-N-cyclohexyl-N-methyl-2-((((2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-7-yl)(phenyl)methylene)amino)oxy)acetamide
InChIKey: VHDUUXNHZLBGHQ-XLVZBRSZSA-N
SMILES: O=C(N(C1CCCCC1)C)CO/N=C(C2=CC=CC=C2)/C3=CC4=C(N=C(NC(C5)=O)N5C4)C=C3
Biological Activity:
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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Revizinone | 99.40% | Revizinone is a novel selective phosphodiesterase (PDE) inhibitor with IC50 values on this enzyme to 0.036 microM. | ||||||||||||||||||||
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References
- Herregods L et al. Haemodynamic effects of R 80122 immediately after cardiopulmonary bypass; preliminary results. Anaesthesia. 1994 Aug;49(8):719-22. [Content Brief]
- Schneider J et al. Cardiac effects of R 79595 and its isomers (R 80122 and R 80123) in an acute heart failure model. A new class of cardiotonic agents with highly selective phosphodiesterase III inhibitory properties. Naunyn Schmiedebergs Arch Pharmacol. 1992 Nov;346(5):563-72. [Content Brief]
- de Cheffoy de Courcelles D et al. Inhibition of human cardiac cyclic AMP-phosphodiesterases by R 80122, a new selective cyclic AMP-phosphodiesterase III inhibitor: a comparison with other cardiotonic compounds. J Pharmacol Exp Ther. 1992 Oct;263(1):6-14. [Content Brief]
- Vandeplassche GM et al. Comparative effects of R 80122, enoximone, and milrinone on left ventricular phosphodiesterase isoenzymes in vitro and on contractility of normal and stunned myocardium in vivo in dogs. J Cardiovasc Pharmacol. 1992 May;19(5):714-22. [Content Brief]
