13406-97-8
13406-97-8
Chemical Structure
ME1071
- CAS No.: 13406-97-8
- Formula:C8H12O4
- Molecular Weight:172.18
IUPAC Name: 2,3-diethylmaleic acid
InChIKey: HAHASQAKYSVXBE-WAYWQWQTSA-N
SMILES: C(=C(\C(O)=O)/CC)(\C(O)=O)/CC
Biological Activity: ME1071 is a metallo-β-lactamase inhibitor. ME1071 inhibits IMP-1, VIM-2, and NDM-1 by blocking the entry of β-lactam compounds through zinc binding. ME1071 exhibits competitive inhibition against IMP-1 and VIM-2, and its activity against IMP-type enzymes is superior to that against NDM/VIM-type enzymes. ME1071 can be used in research on multidrug-resistant Gram-negative bacterial infections[1][2][3][4][5][6].
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ME1071 | ME1071 is a metallo-β-lactamase inhibitor. ME1071 inhibits IMP-1, VIM-2, and NDM-1 by blocking the entry of β-lactam compounds through zinc binding. ME1071 exhibits competitive inhibition against IMP-1 and VIM-2, and its activity against IMP-type enzymes is superior to that against NDM/VIM-type enzymes. ME1071 can be used in research on multidrug-resistant Gram-negative bacterial infections. | |||||||||||||||||||||
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References
- [1]. Xu ZQ, et al. Combating multidrug-resistant Gram-negative bacterial infections. Expert opinion on investigational drugs. 2014 Feb 1;23(2):163-82.
- [2]. Ishii Y, et al. In vitro potentiation of carbapenems with ME1071, a novel metallo-beta-lactamase inhibitor, against metallo-beta-lactamase- producing Pseudomonas aeruginosa clinical isolates. Antimicrobial agents and chemotherapy. 2010 Sep;54(9):3625-9.
- [3]. Bassetti M, et al. New treatment options against gram-negative organisms. Critical Care. 2011 Mar 22;15(2):215.
- [4]. Wachino JI, et al. Sulfamoyl Heteroarylcarboxylic Acids as Promising Metallo-β-Lactamase Inhibitors for Controlling Bacterial Carbapenem Resistance. mBio. 2020 Mar 17;11(2):e03144-19.
- [5]. Yamada K, et al. In vivo efficacy of biapenem with ME1071, a novel metallo-β-lactamase (MBL) inhibitor, in a murine model mimicking ventilator-associated pneumonia caused by MBL-producing Pseudomonas aeruginosa. International journal of antimicrobial agents. 2013 Sep;42(3):238-43.
- [6]. Livermore DM, et al. Activity of carbapenems with ME1071 (disodium 2,3-diethylmaleate) against Enterobacteriaceae and Acinetobacter spp. with carbapenemases, including NDM enzymes. The Journal of antimicrobial chemotherapy. 2013 Jan;68(1):153-8.
