1350821-45-2
Chemical Structure
PF-5177624
- CAS No.: 1350821-45-2
- Formula:C25H25FN8O2
- Molecular Weight:488.52
IUPAC Name: (2R,3R)-3-((6-(4-amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyrazin-2-yl)amino)-2-(4-fluorophenyl)pyrrolidine-1-carbaldehyde
InChIKey: TZOLUHQWLXJGBH-XMSQKQJNSA-N
SMILES: O=CN1[C@@H]([C@@H](CC1)NC2=NC(C(C3=CN(C4=NC=NC(N)=C43)C(C)C)=O)=CN=C2)C5=CC=C(C=C5)F
Biological Activity: PF-5177624 is a specific and potent inhibitor of PDK1, a key enzyme in the PI3K/AKT signaling pathway that is frequently dysregulated in breast cancer. PDK1 phosphorylates AKT at T308 and other substrates, activating downstream signaling pathways that are important for tumor progression. PF-5177624 blocks IGF-1-stimulated PDK1 activity and downstream AKT and p70S6K phosphorylation, reducing cell proliferation and transformation in breast cancer cells[1].
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PF-5177624 | PF-5177624 is a specific and potent inhibitor of PDK1, a key enzyme in the PI3K/AKT signaling pathway that is frequently dysregulated in breast cancer. PDK1 phosphorylates AKT at T308 and other substrates, activating downstream signaling pathways that are important for tumor progression. PF-5177624 blocks IGF-1-stimulated PDK1 activity and downstream AKT and p70S6K phosphorylation, reducing cell proliferation and transformation in breast cancer cells. | |||||||||||||||||||||
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Keywords
