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PF-5177624

PF-5177624 is a specific and potent inhibitor of PDK1, a key enzyme in the PI3K/AKT signaling pathway that is frequently dysregulated in breast cancer. PDK1 phosphorylates AKT at T308 and other substrates, activating downstream signaling pathways that are important for tumor progression. PF-5177624 blocks IGF-1-stimulated PDK1 activity and downstream AKT and p70S6K phosphorylation, reducing cell proliferation and transformation in breast cancer cells.

For research use only. We do not sell to patients.

  • CAS No.: 1350821-45-2
  • Formula: C25H25FN8O2
  • Molecular Weight:488.52
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • PF-5177624 Chemical Structure
    PF-5177624 Chemical Structure
CAS No.: 1350821-45-2
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  • PF-5177624 Chemical Structure
    PF-5177624 Chemical Structure
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  • PF-5177624