1374772-61-8
Chemical Structure
Kocurin
Synonym(s): PM181104; Baringolin
- CAS. Nr.: 1374772-61-8
- Formula:C69H66N18O13S5
- Molecular Weight:1515.70
IUPAC Name: 2-((12S,22Z,32Z,52Z,92Z,132Z,134R,8S,12S,16S)-8-(2-amino-2-oxoethyl)-12-benzyl-16-(4-hydroxybenzyl)-55-methyl-6,10,14,17-tetraoxo-134,135-dihydro-7,11,15-triaza-5(2,4)-oxazola-2,3,9,13(2,4)-tetrathiazola-4(2,3)-pyridina-1(2,1)-pyrrolidinacycloheptadecaphane-46-yl)-N-(3-(((S)-1-((S)-2-((3-((3-amino-3-oxoprop-1-en-2-yl)amino)-3-oxoprop-1-en-2-yl)carbamoyl)pyrrolidin-1-yl)-1-oxopropan-2-yl)amino)-3-oxoprop-1-en-2-yl)thiazole-4-carboxamide
InChIKey: WWWYMYPACSXBTM-GVYUJTEBSA-N
SMILES: CC(OC(C1=CC=C(C2=NC(C(NC(C(N[C@@H](C)C(N3[C@@H](CCC3)C(NC(C(NC(C(N)=O)=C)=O)=C)=O)=O)=O)=C)=O)=CS2)N=C1C4=CSC(C5=CSC([C@@]6([H])N(CCC6)C([C@@H](NC([C@@]7([H])N=C(SC7)[C@@H](NC(C8=CSC([C@@H](N9)CC(N)=O)=N8)=O)CC%10=CC=CC=C%10)=O)CC%11=CC=C(C=C%11)O)=O)=N5)=N4)=N%12)=C%12C9=O
Biological Activity: Kocurin (PM181104) is a thiazolyl cyclic-peptide antibiotic. Kocurin inhibits bacterial growth by impeding bacterial protein biosynthesis during the translation phase. Kocurin has strong inhibitory activity against Gram-positive bacteria, but no activity against fungi and Gram-negative bacteria[1].
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Kocurin | Kocurin (PM181104) is a thiazolyl cyclic-peptide antibiotic. Kocurin inhibits bacterial growth by impeding bacterial protein biosynthesis during the translation phase. Kocurin has strong inhibitory activity against Gram-positive bacteria, but no activity against fungi and Gram-negative bacteria. | |||||||||||||||||||||
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Keywords
