1394808-82-2
Chemical Structure
Samelisant free base
Synonym(s): SUVN-G3031 free base
- CAS No.: 1394808-82-2
- Formula:C21H31N3O3
- Molecular Weight:373.49
IUPAC Name: N-(4-((1-cyclobutylpiperidin-4-yl)oxy)phenyl)-2-morpholinoacetamide
InChIKey: LNXDUSQEXVQFGP-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(OC2CCN(C3CCC3)CC2)C=C1)CN4CCOCC4
Biological Activity: Samelisant (SUVN-G3031) free base is a potent and selective histamine H3 receptor (H3R) inverse agonist with good brain penetration and oral bioavailability. Samelisant free base has a similar binding affinity towards human (hH3R; Ki=8.7 nM) and rat (rH3R;Ki=9.8 nM) H3R indicating no inter-species differences. Samelisant free base can be used for the research of sleep-related disorders[1].
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Samelisant free base | Samelisant (SUVN-G3031) free base is a potent and selective histamine H3 receptor (H3R) inverse agonist with good brain penetration and oral bioavailability. Samelisant free base has a similar binding affinity towards human (hH3R; Ki=8.7 nM) and rat (rH3R;Ki=9.8 nM) H3R indicating no inter-species differences. Samelisant free base can be used for the research of sleep-related disorders. | |||||||||||||||||||||
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Keywords
