1399690-75-5
Chemical Structure
Chaetoglobosin Vb
- CAS No.: 1399690-75-5
- Formula:C32H36N2O5
- Molecular Weight:528.64
IUPAC Name: (3S,3aR,6S,6aR,10S,10aR,13aR,15aR,E)-3-((1H-indol-3-yl)methyl)-6,12-dihydroxy-4,5,10,11-tetramethyl-2,3,3a,6,6a,9,10,10a,13a,14-decahydro-1H-cyclopenta[7,8]cyclodeca[1,2-d]isoindole-1,13,15-trione
InChIKey: PRTGSLLKDHOTJT-CIQYLYMDSA-N
SMILES: O=C1N[C@@H](CC2=CNC3=C2C=CC=C3)[C@]4([H])C(C)=C(C)[C@@H](O)[C@@](/C=C/C[C@H](C)[C@]5([H])[C@@](C(C(O)=C5C)=O)([H])C6)([H])[C@]14C6=O
Biological Activity: Chaetoglobosin Vb is a cytochalasin alkaloid with anti-inflammatory and antioxidant activities. Chaetoglobosin Vb attenuates LPS (HY-D1056)-induced TLR4 inflammatory signaling and IFN-β release by downregulating TRIF, MyD88, TLR4 mRNA and IRF7 expression. Chaetoglobosin Vb downregulates the expression and release of inflammatory mediators such as iNOS, COX-2, TNF-α and IL-6 by blocking MAPK/NF-κB pathway activation. Chaetoglobosin Vb reduces excessive ROS production and protects SOD enzyme activity against LPS-induced oxidative stress. Chaetoglobosin Vb inhibits the growth of certain bacteria and radish seedling roots. Chaetoglobosin Vb can be used in research related to colorectal cancer, bacterial infection, and radish growth[1][2][3][4].
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Chaetoglobosin Vb | Chaetoglobosin Vb is a cytochalasin alkaloid with anti-inflammatory and antioxidant activities. Chaetoglobosin Vb attenuates LPS (HY-D1056)-induced TLR4 inflammatory signaling and IFN-β release by downregulating TRIF, MyD88, TLR4 mRNA and IRF7 expression. Chaetoglobosin Vb downregulates the expression and release of inflammatory mediators such as iNOS, COX-2, TNF-α and IL-6 by blocking MAPK/NF-κB pathway activation. Chaetoglobosin Vb reduces excessive ROS production and protects SOD enzyme activity against LPS-induced oxidative stress. Chaetoglobosin Vb inhibits the growth of certain bacteria and radish seedling roots. Chaetoglobosin Vb can be used in research related to colorectal cancer, bacterial infection, and radish growth. | |||||||||||||||||||||
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References
- [1]. Zhang H, et al. Anti-inflammatory and antioxidant effects of Chaetoglobosin V in LPS-induced RAW264.7 cells: Achieved via the MAPK and NF-κB signaling pathways. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Jan;147:111915. [Content Brief]
- [2]. Zhan J, et al. Study on antioxidant synergistic anti-inflammatory peptide from giant salamander (Andrias davidianus): functional mechanism and delivery by nano-starch. Food Science and Human Wellness. 2026 Jul 1;15(7):9250512.
- [3]. Gao W, et al. Antibacterial activity against drug-resistant microbial pathogens of cytochalasan alkaloids from the arthropod-associated fungus Chaetomium globosum TW1-1. Bioorganic chemistry. 2019 Mar;83:98-104.
- [4]. Li H, et al. Chaetoglobosins from Chaetomium globosum, an endophytic fungus in Ginkgo biloba, and their phytotoxic and cytotoxic activities. Journal of agricultural and food chemistry. 2014 Apr 30;62(17):3734-41.
