14107-37-0
14107-37-0
Chemical Structure
Alphadolone
Synonym(s): Alfadolone
- CAS No.: 14107-37-0
- Formula:C21H32O4
- Molecular Weight:348.48
IUPAC Name: (3R,5S,8S,9S,10S,13S,14S,17S)-3-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethylhexadecahydro-11H-cyclopenta[a]phenanthren-11-one
InChIKey: XWYBFXIUISNTQG-VKMGZQQJSA-N
SMILES: C[C@]1([C@H](CC[C@]1([C@@]2(CC[C@]3(C[C@@H](CC[C@@]3([C@]24[H])C)O)[H])[H])[H])C(CO)=O)CC4=O
Biological Activity: Alphadolone is a GABAA receptor positive allosteric modulator. Alphadolone has antinociceptive effects. Alphadolone causes general anaesthesia[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Alphadolone | 98.71% | Alphadolone is a GABAA receptor positive allosteric modulator. Alphadolone has antinociceptive effects. Alphadolone causes general anaesthesia. | ||||||||||||||||||||
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References
- [1]. Halsey MJ, et al. Pressure reversal of alphaxalone/alphadolone and methohexitone in tadpoles: evidence for different molecular sites for general anaesthesia. Br J Pharmacol. 1986 Oct;89(2):299-305. [Content Brief]
- [2]. Nadeson R, et al. Antinociceptive properties of neurosteroids II. Experiments with Saffan and its components alphaxalone and alphadolone to reveal separation of anaesthetic and antinociceptive effects and the involvement of spinal cord GABA(A) receptors. Pain. 2000 Oct;88(1):31-39. [Content Brief]
Keywords
