14149-43-0
Chemical Structure
Trimethidinium methosulfate
- CAS No.: 14149-43-0
- Formula:C19H42N2O8S2
- Molecular Weight:490.68
IUPAC Name: mono(1,3,8,8-tetramethyl-3-(3-(trimethylammonio)propyl)-3-azabicyclo[3.2.1]octan-3-ium) mono(methyl sulfate)
InChIKey: ZOSQTCOGKFRDET-UHFFFAOYSA-L
SMILES: O=S([O-])(OC)=O.CC1(C2CCC1(C[N+](CCC[N+](C)(C)C)(C2)C)C)C.O=S([O-])(OC)=O
Biological Activity: Trimethidinium methosulfate is an orally active ganglionic blocker with central antihypertensive activity. Trimethidinium methosulfate inhibits the conduction of sympathetic ganglia and reduces vascular contraction. Trimethidinium methosulfate acts on the cerebrovascular motor center and lowers peripheral vascular resistance. Trimethidinium methosulfate has cholinergic nerve inhibitory side effects, but they are relatively mild. Trimethidinium methosulfate can be used in hypertension research[1][2].
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Trimethidinium methosulfate | Trimethidinium methosulfate is an orally active ganglionic blocker with central antihypertensive activity. Trimethidinium methosulfate inhibits the conduction of sympathetic ganglia and reduces vascular contraction. Trimethidinium methosulfate acts on the cerebrovascular motor center and lowers peripheral vascular resistance. Trimethidinium methosulfate has cholinergic nerve inhibitory side effects, but they are relatively mild. Trimethidinium methosulfate can be used in hypertension research. | |||||||||||||||||||||
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- [1]. PELNER L, WALDMAN S. Trimethidinium methosulfate in the treatment of moderate and severe hypertension. J Am Geriatr Soc. 1960 Mar;8:168-76. [Content Brief]
- [2]. BORHANI NO. Use of trimethidinium methosulfate (a new ganglionic blocking agent) in the treatment of hypertension. Ann Intern Med. 1959 Nov;51:983-92. [Content Brief]
Keywords
